Description
Key Aspects of VIP Peptide:
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- Functions: As a neurotransmitter and neurohormone, VIP regulates intestinal secretion, relaxes airway smooth muscle, and acts as a vasodilator.
- Immune Regulation: VIP is heavily involved in controlling innate and adaptive immune responses, exerting anti-inflammatory effects
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- Clinical Applications: VIP has been tested for treating erectile dysfunction (e.g., Invicorp), pulmonary hypertension, and chronic sarcoidosis.
- Pathology Link: Elevated VIP levels in the blood are used to diagnose VIPoma, a rare type of neuroendocrine tumour usually located in the pancreas.
- Mechanism: It acts via G protein-coupled receptors (VPAC1, VPAC2, and PAC1) to modulate cellular activities.
Clinical Significance & Research
Respiratory Role: VIP is an important inhibitory transmitter in the lung that controls airway tone and has potential as an inhaled agonist for treating asthma.
- Neuroprotection: Studies are exploring the role of VIP and its receptors in treating neurological disorders like Alzheimer’s, Parkinson’s, and Autism Spectrum Disorders.
- Inflammatory Disease: VIP helps suppress autoimmune disease progression in animal models by inducing regulatory T cells.
- Diagnostic Utility: Testing for vasoactive intestinal peptide is used to investigate persistent, severe watery diarrhea.
- Reconstitution in Bac Water: 2ml of Bac Water, starting dose, 10 units sub injection.
Research Use Only: Not for human or veterinary use.
